For the record, I had this happen to me when I changed the Mail service settings via dragging a .plist file onto the Mail Settings window in Server Admin.
The affected file is /private/etc/postfix/main.cf:
Scroll to the bottom of the config file.
Somehow, Server Admin changed the “mailbox_transport” value to “0” – it should be set to cyrus. Changing it back and restarting Mail services resumed normail mail operations for me.
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