The two issues at the moment are going to be:
1) Lack of FireWire and built in ethernet. The natural solutions here are: USB-Ethernet adapter and a NetBoot set (made for this computer) or a bootable USB drive (probably even the USB key they ship with).
2) As you mention, this is going to be a custom build of the OS, and until a dot-upgrade that supports it comes our your images (and NetBoot sets) are going to have to be custom to suport them.
Other than that these are just the latest iteration of the MacBook Air line. Treat them like you would any other MacBook Air.
Oh… and I have had my hands on a couple, and they are really nice looking.
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