Yes, you can. But you REALLY don’t want to use CIFS/SMB on the Mac side of things.
You would be much better installing ExtremeZIP on the windows server(s) to provide native AFP connectivity to the Macs.
OR
Use the Mac server(s) and the SMB service to provide the home directories to the PC clients. You’ll have to repoint all of the users’ home directory paths to the Mac server (in their AD ‘profile’ tab). Seems to work well, especially in 10.5 Server and onwards.
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